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Obesity alone increases the risk for issues like diabetes, heart disease, and fatty liver

Data were extracted as follows: (1) species, number exposed to drug of interest, number of controls, timing and duration of exposure, dose (drug/kg/time-interval and equivalents to maximum recommended human dosage or clinical dosage), fetal effects of maternal GLP-1 agonist or SGLT2 inhibitor exposure, (2) species, number exposed to drug of interest, number of controls, timing and duration of exposure, dose (drug/kg/time-interval and equivalents to maximum recommended human dosage or clinical dosage), the transfer of GLP-1 agonist or SGLT2 inhibitor in maternal milk and the effect of exposure during lactation on the neonate

10.1007/s00204-019-02597-1 46 JasaniB.WeiszD

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In our PCOS models, GLP1/E may ameliorate hypothalamic inflammation, as reflected by a reduced expression of proteins related to the immune system, and attenuate apoptotic responses

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